Autism spectrum disorders (ASDs) are
neurodevelopmental disorders characterized by difficulties in
communication and by repetitive and stereotypic behaviors, as well as
by social impairment, attention, cognitive, and learning defects.
ASDs have increased significantly to 1/150 children, and the reasons
for this increase are still not clear. There is no reliable screening
test, and no definite pathogenesis or curative therapy. However, a
recent review of publications on ASDs pathogenesis and treatment with
emphasis on neuroimmune processes and new therapeutic approaches found
increased oxidative stress and immune dysregulation are present in
ASDs, and unique combinations with antioxidant and anti-inflammatory
flavonoids hold promise for mitigating ASD.
(Source: Theoharides TC, Kempuraj D, Redwood L; Autism: an emerging
'neuroimmune disorder' in search of therapy. Expert Opinion in
Pharmacotherapy 2009;10(13):2127-43.) |
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Fantastic News For Kids and Parents
Health
practitioners have discovered Enzogenol as a nutritional support for
children with symptoms of hyperactivity, attention deficits and
behaviour problems.
Several paediatricians
specialising in the treatment of children with ABC disorders have found
ENZO Professional a very useful adjunct nutritional help for these
kids. The ABC = Attention Behaviour Continuum comprises a number of
conditions that include Attention Deficit Disorder, with and without
Hyperactivity, Asperger's Syndrome, Autism and other conditions that
share similar behavioural phenotypes. (Read more about Enzogenol and the scientific evidence)
Dr. Leila Masson (www.leilamasson.com) from Auckland, New Zealand had this to say about her experience: “Enzogenol
is a safe and effective alternative for children with hyperactivity and
problems concentrating. I have noticed improvements in my patients
within a few weeks of starting this potent antioxidant. Parents and
teachers consistently report that the children are calmer and more
focused. I recommend a trial of Enzogenol for any child with features
of ADHD or autism.” |
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Knowledge Links:
Autism New Zealand
Australian Psychological Society
Mindd Foundation (offers integrative medicine practitioner search)
Health Insite:ADHD
MedlinePlus:
ADHD
Asperger's
Autism
US NIH:
ASD
ADHD
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The parents feedback has been great! More and more children are reaping the benefits of being calmer, more attentive and socialising much better with other kids. The case studies below attest to the success of Enzogenol as part of a nutritional approach.
Below is a small selection of case studies that have been provided by parents directly to Enzo Nutraceuticals Ltd using a case study questionnaire. The parent gave consent for the information to be used here as long as it is kept anonymous. The information provided has not been altered in any other way.
| Case 12: D. C., boy, age 8
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| Diagnosis: Autism spectrum disorder
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First diagnosed at age: 8
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Is your child predominantly inattentive, predominantly hyperactive-impulsive, or a combination of both?
impulsive, emotional outbursts.
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| Medication (pharmaceutical):Risperidone.
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| Supplementation (nutritional): Sam E
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| ENZO Professional Supplementation: started Feb 2009, 2 caps per day
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| Special way of dosing: swallows with water
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OBSERVATIONS
1. Have you seen any changes in your child after starting on Enzo Professional? YES?
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Please describe changes: within 2 days, less emotional outbursts, more cheerful, calmer.
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2. Have you noticed any unwanted effects / side effects from Enzo Professional? No!
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3. Have you noticed any changes on the following after starting your child on Enzo Professional? If so, please comment:
Hyperactivity: n/a
Irritability: improved
Attention span: n/a
Concentration: n/a
Listening ability: n/a
Socialisation skills: improved
Discipline: improved
School performance: improved
Sleep: n/a
Appetite: n/a
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4. Is there anything else you might have noticed that you feel might be helpful to add here? no die off
I have removed the risperidone and Sam E successfully (which we had tried before unsuccessfully)
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Date this questionnaire was filled out: 9 Mar 2009
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| Case 9: N. P., boy, age 5
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| Diagnosis: ADHD with oppositional defiance disorder (Hyperactivity Major)
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First diagnosed at age: 4
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Is your child predominantly inattentive, predominantly hyperactive-impulsive, or a combination of both?
Hyperactive / impulsive / oppositional defiant.
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| Medication (pharmaceutical): Rubifen 10.
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| Supplementation (nutritional): Probiotic, Multivitamin, Vit C, Magnesium, Evwening Primrose oil, Epsom Salt Baths, Zinc Pfeiffer Primer IV, Flaxoil.
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| ENZO Professional Supplementation: started 24 Sep 2008, 2 caps per day
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| Special way of dosing: 1 cap morning straight after food,. Second after lunch or 3 pm.
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OBSERVATIONS
1. Have you seen any changes in your child after starting on Enzo Professional? YES.
If YES, how long after starting Enzo Professional did you notice changes? 1 day.
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| Please describe changes: It appeared to work quickly - I noticed once dosed in the morning he seemed calmer in afternoon. At first I thought that it was a fluke, but the next day he seemed to be calmer, too. With the calmness came better clearer speech. Good listening, more receptive to requests to comply. |
2. Have you noticed any unwanted effects / side effects from Enzo Professional? No.
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3. Have you noticed any changes on the following after starting your child on Enzo Professional? If so, please comment:
Hyperactivity: Calmer.
Irritability: Less.
Attention span:Much better.
Concentration: Much better.
Listening ability: Greatly improved.
Discipline: Better - more receptive, compliant.
School performance: Better.
Sleep: OK.
Appetite: No noticable change.
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4. Is there anything else you might have noticed that you feel might be helpful to add here?
I did drop the afternoon rubifen 10 to see what reaction we would get. He coped so well that I continued it - only dosing when the situation called for it.
Really happy with the result N has had, will continue with this product as part of his supplement regime. Most days he has only 2/3 doses of Rubifen. N starting school on 20th Nov. Many Thanks, F.P.
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Date this questionnaire was filled out: 10 Nov 2008
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| Case 6: D. M-W., boy, age 8
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| Diagnosis: Asperger's Syndrome / ADHD
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First diagnosed at age: 6
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Is your child predominantly inattentive, predominantly hyperactive-impulsive, or a combination of both?
Combination.
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| Medication (pharmaceutical): None.
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| Supplementation (nutritional): Herbal anti-streptococcal mix, Biocidin, Probiotic, B-complex, Magnesium, Fish oil, Evening primrose oil, Zinc-Pfeiffer primer, Selenium, DMG
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| ENZO Professional Supplementation: started Feb 2008, 2 caps per day
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| Special way of dosing: Capsule fine.
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OBSERVATIONS
1. Have you seen any changes in your child after starting on Enzo Professional? YES? (Difficult to isolate if specifically due to Enzo as other suppl started at the same time.)
If YES, how long after starting Enzo Professional did you notice changes? not sure.
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Please describe changes: This year D is calmer, able to concentrate in classroom setting for short periods. Will comply with instructions.
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2. Have you noticed any unwanted effects / side effects from Enzo Professional? No!
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3. Have you noticed any changes on the following after starting your child on Enzo Professional? If so, please comment:
Hyperactivity: Few episodes - was little problem.
Irritability: This was a problem - major meltdowns. Much more settled. Very few meltdowns.
Attention span: Longer now so can work/concentrate in bursts 15min.
Concentration: Can now work in classroom. Previously had to be separated with teacher aid.
Listening ability: All related.
Socialisation skills: A lot more confident and social. Can play without having to dominate. Happy. Proactively joining school clubs and sport.
Discipline: Far fewer "time outs". Will follow direction when being told off.
School performance: He is doing work for the first time since starting school! Huge change.
Sleep: Still restless.
Appetite: Always big appetite.
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4. Is there anything else you might have noticed that you feel might be helpful to add here?
I've been taking it (Enzo Professional) and, perhaps wishful thinking, feel sharper thinking.
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Date this questionnaire was filled out: 11 April 2008
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| Case 3: D. M., boy, age 6
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| Diagnosis: Autism
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First diagnosed at age: 1 1/2
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Is your child predominantly inattentive, predominantly hyperactive-impulsive, or a combination of both?
Both!
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| Medication (pharmaceutical): -
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| Supplementation (nutritional): Biomedical P5P, Zn, Mg
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| ENZO Professional Supplementation: started Dec 2007, 1 cap per day
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| Special way of dosing: Capsule given in mashed fruit. He swallows it whole.
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OBSERVATIONS
1. Have you seen any changes in your child after starting on Enzo Professional? YES!
If YES, how long after starting Enzo Professional did you notice changes? 1 week!
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Please describe changes: D is less hyperactive, more attentive and calm. Concentration is better. He wants to interact with other people. Responds to people talking to him. He is much more aware what is going on around him.
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2. Have you noticed any unwanted effects / side effects from Enzo Professional? No!
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3. Have you noticed any changes on the following after starting your child on Enzo Professional? If so, please comment:
Hyperactivity: Less hyperactive!
Irritability: Less irritable!
Attention span: Much better!
Concentration: More concentration!
Listening ability: Yes, very much so!
Socialisation skills: Interested in things going on around him!
Discipline: Much better because of his listening!
School performance: Much calmer!
Sleep: He has always been a good sleeper, no change!
Appetite: Just the same!
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4. Is there anything else you might have noticed that you feel might be helpful to add here?
Prior to Enzo Professional D would only be able to tolerate a trip to the shopping mall, kids party or supermarket for a max of 1 hour. Now he is great for 2-3 hours!!! Fabulous improvement.
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Date this questionnaire was filled out: 12 April 2008
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| Case 2: A. W., girl, age 6
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| Diagnosis: A.S.D.
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First diagnosed at age: 2
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| Medication (pharmaceutical): Nilstat, Melatonin
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| Supplementation (nutritional): Vitamin C, Mg, Zn, Se, probiotic, iodine, floradix, B12, Evening Primrose oil, Cod Liver Oil
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| ENZO Professional Supplementation: started Nov 2007, 2 caps (1 am, 1 pm)
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| Special way of dosing: Capsule content sprinkled onto a spoon of soy yoghurt
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OBSERVATIONS
1. Have you seen any changes in your child after starting on Enzo Professional? YES!
If YES, how long after starting Enzo Professional did you notice changes? 3 months!
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Please describe changes: Calmer. Happier. Complient. Focused at school. Learning better.
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2. Have you noticed any unwanted effects / side effects from Enzo Professional? No!
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3. Have you noticed any changes on the following after starting your child on Enzo Professional? If so, please comment:
Hyperactivity: No.
Irritability: Yes. Much calmer!
Attention span: Yes. Much better!
Concentration: Yes. Improved!
Listening ability: Yes. Understands well!
Socialisation skills: Yes. Making friends!
Discipline: Yes. Much more obedient!
School performance: Yes. Brilliant!
Sleep: Yes. Sleeping through!
Appetite: Yes. Eating breakfast.
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4. Is there anything else you might have noticed that you feel might be helpful to add here?
Nice company to deal with. Friendly + helpful.
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Date this questionnaire was filled out: 11 April 2008
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#
The Science
The latest clinical study on Enzogenol has investigated effects on cognitive function in healthy people (Pipingas et al. 2008). This study demonstrated improved performance on cognitive tasks after only 5 weeks of treatment. Important for the application in ADHD, Asperger’s and Autism are the results from the neuroimaging analyses. The Enzogenol study used steady-state probe topography (SSPT) neuroimaging to investigate changes in brain activity associated with the treatment. This is a powerful technique established at the Brain Sciences Institute (BSI) of
Swinburne
University in
Melbourne. With this method the researchers found significant changes in patterns of brain activity that were associated with the improved performance. Professor Silberstein of BSI had previously studied the effects of methylphenidate (Ritalin) on brain activities in children with ADHD using the same technology, and found specific changes in the way the kid’s brains worked after an acute dose of Ritalin. It is these effects of the drug in the brain that lead to the normalization in behaviour and allow the children to concentrate better. Interestingly, very similar changes were seen with the Enzogenol, but these changes observed with Enzogenol were milder and more supple than those observed with the drug Ritalin. These results have given some initial evidence that Enzogenol may help to improve brain activities naturally to reach similar effects to Ritalin but without the drug-sledgehammer and the risk of side effects.
At this time we can only speculate on the possible mechanisms of action that could explain the effects Enzogenol has on children with behavioural problems. Possibilities include:
1. Affecting the antioxidant status – reducing free radical load/oxidative stress
2. Direct effects modifying signal transduction in the CNS from phenolic compounds and their metabolites entering circulation
3. Indirect effects by influencing the gut-brain axis, i.e.
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reducing leaky gut symptoms that may contribute to, or underlie, the behavioral phenotype
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affecting levels of circulating neuroactive compounds originating from the enteric nervous system
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modifying/reducing negative effects of dietary antigens
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affecting metal load in the gut through strong metal-chelating properties of the proanthocyanidin compounds in Enzogenol